Sjögren's disease & overlap diseases
Salivary gland 18F-FDG-PET/CT uptake patterns in Sjögren's syndrome and giant cell arteritis patients
Authors' conclusion
Although 18F-FDG-uptake was not increased in parotid and submandibular glands of pSS patients, increased 18F-FDG-uptake in tubarial glands of pSS patients might indicate a role for these glands in pSS. Furthermore, parotid and submandibular glands may be affected by local vasculitis in GCA.
Study context
- Population
- Patients aged ≥50 years with primary Sjögren's syndrome (pSS), giant cell arteritis (GCA) or lung cancer who underwent 18F-FDG-PET/CT
- Exposure
- pSS vs GCA vs non-autoimmune controls
- Outcome
- Salivary gland 18F-FDG uptake (visual evaluation and standardised uptake values (SUV) in salivary and lacrimal glands)
Methodological detailsage-matched
- Age-matched
Main finding
As reported in the abstract
Salivary gland 18F-FDG uptake
- pSS: no increased 18F-FDG uptake in parotid or submandibular gland vs the other two groups
- Tubarial gland: significantly higher SUVmax in pSS
- Submandibular gland: significantly higher SUVmax in GCA than the other two groups
Observational data: associations, not effects.
Further findings
GCA: cranial artery 18F-FDG positivity near parotid and submandibular glands
- Visual positivity of related cranial arteries associated with significantly higher salivary gland SUVmax in GCA
Original publication
Salivary gland 18F-FDG-PET/CT uptake patterns in Sjögren's syndrome and giant cell arteritis patients. Clin Exp Rheumatol. Published 12 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →