Spondyloarthritis & psoriatic arthritis
Role of the S1P/S1PR axis in inflammation and structural damage in psoriatic arthritis: a cross-sectional study with clinical, biochemical and imaging correlation
Authors' conclusion
The S1P/S1PR axis is dysregulated in PsA and is associated with disease progression.
Study context
- Population
- Patients with psoriatic arthritis (PsA) and healthy controls43 PsA, 21 controls
- Participants
- 64 patients
- Exposure
- PsA vs healthy controls
- Recent-onset PsAn = 16
- Established PsA (EPsA)n = 27
- Healthy controlsn = 21reference
- Outcome
- Serum S1P and S1PR levels (ELISA) and their relation to clinical activity, imaging findings and PsA stage
Methodological detailsobservational
- Observational
Main finding
As reported in the abstract
- S1P significantly higher in PsA vs controls
- p=0.013
- Highest S1P values in EPsA subgroup
- p=0.009
- S1PR significantly higher in patients with US-detected Achilles enthesitis
- p=0.046
- S1PR significantly higher in patients with bone proliferation/structural damage
- p=0.03
Observational data: associations, not effects.
Further findings
Cortical volumetric bone mineral density (BMD)
- Significantly higher in EPsA vs controls
- P = 0.027
Original publication
Role of the S1P/S1PR axis in inflammation and structural damage in psoriatic arthritis: a cross-sectional study with clinical, biochemical and imaging correlation. RMD Open. Published 8 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →