Risk factors for mortality in 1528 Brazilian childhood-onset systemic lupus erythematosus patients
Authors' conclusion
This study confirmed that the recent mortality rate in cSLE in Brazil is low, but still of concern. NP-SLE and CKD were the main risk factors for mortality, indicating that the magnitude of these manifestations was significantly high.
Study context
- Population
- Childhood-onset SLE patients followed in 27 paediatric rheumatology tertiary centres in Brazil
- Participants
- 1,528 patients27 centres
- Exposure
- Deceased cSLE patients vs survivors
- Deceasedn = 63
- Outcome
- Mortality and its risk factors
Methodological detailsmulticentre, Cox regression, Kaplan-Meier
- Multicentre
- Cox regression
- Kaplan-Meier
Main finding
As reported in the abstract
Mortality
Deceased
4.1%
63
HR
- NPSLE as risk factor for mortality
- 2.56 (95% CI 1.48-4.42)
- Chronic kidney disease (CKD) as risk factor for mortality
- 4.33 (95% CI 2.33-4.72)
Observational data: associations, not effects.
Further findings
Characteristics of deaths
- Female
- 53/63 (84.1%)
- Median age at death, years (9.4-13.1)
- 11.9
- Median time from diagnosis to death, years (0.5-5.3)
- 3.2
- Sepsis as main cause of death
- 27/63 (42.8%)
- Opportunistic infections as cause of death
- 7/63 (11.1%)
- Alveolar haemorrhage as cause of death
- 6/63 (9.5%)
Overall survival after cSLE diagnosis · 5, 10 and 15 years
- 5 years
- 97%
- 10 years
- 95.4%
- 15 years
- 93.8%
Original publication
Risk factors for mortality in 1528 Brazilian childhood-onset systemic lupus erythematosus patients. Lupus. Published 18 April 2023. doi:10.
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