Rheumatoid arthritis macrophages are primed for inflammation and display bioenergetic and functional alterations
Authors' conclusion
This study demonstrates a unique inflammatory and metabolic phenotype of RA monocyte-derived macrophages and identifies a key role for NAMPT and STAT3 signalling in regulating this phenotype.
Study context
- Population
- CD14+ monocytes and 'M1/M2' macrophages from RA and healthy control (HC) blood
- Comparison
- RA vs HC monocytes and monocyte-derived macrophages
- Outcome
- Inflammatory and metabolic phenotype of RA vs HC monocytes/macrophages
Methodological detailsex vivo, RNA-sequencing (RNA-seq) transcriptomic analysis
- Ex vivo
- RNA-seq transcriptomic analysis
Main finding
As reported in the abstract
- Circulating RA monocytes hyper-inflammatory upon stimulation, significantly higher expression of key cytokines vs HC, maintained upon differentiation into polarized macrophages
- P < 0.05
Original publication
Rheumatoid arthritis macrophages are primed for inflammation and display bioenergetic and functional alterations. Rheumatology (Oxford). Published 18 November 2022. doi:10.
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