Systemic sclerosis & Raynaud's

Reporting and Representativeness of Race, Ethnicity, and Socioeconomic Status in Systemic Sclerosis Randomized Trials: An Observational Study

Arthritis Care Res (Hoboken)Published Systematic review of randomised controlled trials

Authors' conclusion

Documentation of race/ethnicity and socioeconomic status is poor in RCTs on SSc.

Study context

Population
Published randomized controlled trials (RCTs) on systemic sclerosis (SSc) indexed in PubMed, from 2000 onward
Participants
6,693 participants106 studies
Outcome
Reporting of race/ethnicity and socioeconomic status of participants in SSc RCTs, and representativeness of ethnic/racial groups
Methodological detailsobservational study, multivariable logistic regression, comparison with US demographic data, Studies mostly conducted in Europe (42%) or North America (25%), published after 2010 (74%)
  • Observational study
  • Multivariable logistic regression
  • Comparison with US demographic data
  • Studies mostly conducted in Europe (42%) or North America (25%), published after 2010 (74%)

Pooled result

As reported in the abstract

Papers reporting patients' socioeconomic status
2

Further pooled results

Representation of racial/ethnic groups in studies reporting race/ethnicity

White
79%
Asian
7%
African American
6%

Representation of African American patients in US studies (sensitivity analysis)

Underrepresentation of African American patients in 2000-2010, but not later
  • Sensitivity analysis limited to studies from the US

Original publication

Reporting and Representativeness of Race, Ethnicity, and Socioeconomic Status in Systemic Sclerosis Randomized Trials: An Observational Study. Arthritis Care Res (Hoboken). Published 13 February 2023. doi:10.1002/acr.25059

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