Spondyloarthritis & psoriatic arthritis
Renal involvement in ankylosing spondylitis: a retrospective, population-based cohort study using data from the TriNetX Global Network
Main finding · CKDResult — go to the resultHazard ratio 2.51 95% CI 2.21–2.84Authors' conclusion
AS confers a broad, multifactorial increase in renal morbidity.
Study context
- Population
- Adults with ankylosing spondylitis (AS) and matched controls, TriNetX Global Collaborative Network of anonymised electronic health records
- Exposure
- AS vs propensity score-matched controls
- Outcome
- Chronic kidney disease (CKD)
Methodological detailspopulation-based, propensity score matched 1:1, Cox models, prespecified sensitivity analyses
- Population-based
- Propensity score matched 1:1
- Cox models
- Prespecified sensitivity analyses
Main finding
As reported in the abstract
Hazard ratio
2.51
95% CI 2.21–2.84
ASvs Controls
HR 2.51 (95% CI 2.21–2.84)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR (95% CI) | |
|---|---|---|
| Dialysis initiation | 7.58 (6.19–9.27) | |
| Acute kidney injury | 2.18 (2.03–2.35) | |
| Glomerular diseases | 2.06 (1.71–2.49) | |
| 0.10.31310Hazard ratio (log scale) |
Prespecified sensitivity analyses
- Associations were consistent across prespecified sensitivity analyses
Original publication
Renal involvement in ankylosing spondylitis: a retrospective, population-based cohort study using data from the TriNetX Global Network. RMD Open. Published 13 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →