Relationship of Fatigue, Pain Interference, and Physical Disability in Children Newly Diagnosed With Juvenile Idiopathic Arthritis
Authors' conclusion
Our findings suggest both fatigue and pain interference are independently associated with physical disability in children newly diagnosed with JIA, and the effect of pain interference may be partly mediated by fatigue.
Study context
- Population
- Children enrolled within three months of juvenile idiopathic arthritis (JIA) diagnosis in the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry, February 2017–May 2023; parent-proxy PROMIS fatigue and pain interference and Childhood HAQ-DI at enrollment61.4% female
- Participants
- 855 children
- Outcome
- Relationships among fatigue, pain interference and physical disability; whether fatigue mediates the pain interference–physical disability relationship
- Follow-up
- Registry enrollment
Methodological detailsregistry-based (CAPRI Registry), Pearson correlations, multiple linear regression, structural equation modeling
- Registry-based (CAPRI Registry)
- Pearson correlations
- Multiple linear regression
- Structural equation modeling
Main finding
As reported in the abstract
Fatigue correlated with pain interference (r), P < 0.001
0.72
Fatigue correlated with physical disability (r), P < 0.001
0.60
Pain interference associated with physical disability, adjusted for fatigue and confounders (β), P < 0.001
0.027
Fatigue associated with physical disability, adjusted for pain interference and confounders (β), P < 0.001
0.013
Observational data: associations, not effects.
Further findings
Severe fatigue and severe pain interference (prevalence) · registry enrollment
- Severe fatigue
- 15.6%
- Severe pain interference
- 7.3%
- Most reported fatigue and pain interference scores similar to the reference population; wide variation across JIA categories
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →