Regulatory T and B cells in pediatric Henoch–Schönlein purpura: friends or foes?
Authors' conclusion
In pediatric HSP, immune activation persists in spite of an increase in Th3 and Tregs.
Study context
- Population
- Children with henoch-Schönlein purpura (HSP) (acute phase or remission) and age-matched healthy controls3 groups of children
- Participants
- 30 / 30 / 40
- Exposure
- Acute HSP vs HSP in remission vs healthy controls
- Acute HSPn = 30
- Remitting HSPn = 30
- Healthy controls (HCs)n = 40reference
- Outcome
- Treg frequencies
Methodological detailsage-matched healthy controls, flow cytometry, ELISA and Luminex
- Age-matched healthy controls
- Flow cytometry
- ELISA and Luminex
Main finding
As reported in the abstract
Acute HSP vs Remitting HSP: P = 0.002 · Acute HSP vs HCs: P = 0.003
Observational data: associations, not effects.
Further findings
| Outcome | HCs | P value |
|---|---|---|
| Activated Th3 cells (FoxP3 + Th3 cells)HSP vs HCs · tend to be more abundant in HSP | 43.30% (range 40.20–49.32) | P = 0.135 |
- Activated Th3 cells (FoxP3 + Th3 cells): HSP 78.43% (range 50.62–80.84)
Serum IgA, IL-17, latency-associated peptide; TNF-alpha, IL-1-beta, IL-6
- IgA, IL-17 and LAP significantly higher in HSP than HCs
- TNF-alpha, IL-1-beta and IL-6 non-significantly higher in HSP than HCs
Bregs
- Bregs identical between the groups
- Breg percentage lower in patients with renal impairment than without
IgA production after Treg removal in PBMC culture
- Treg removal increased IgA production in HSP
Original publication
Regulatory T and B cells in pediatric Henoch–Schönlein purpura: friends or foes? Arthritis Res Ther. Published 16 February 2024. doi:10.
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