Common Seasonal Pathogens and Epidemiology of Henoch-Schönlein Purpura Among Children
Authors' conclusion
This study found that significant changes in the incidence of HSP simultaneously with major shifts in circulating pathogens after NPIs for the COVID-19 pandemic indicated that approximately 60% of HSP incidence was potentially associated with pneumococcus and group A streptococcus.
Study context
- Population
- Children younger than 18 years hospitalized for henoch-Schönlein purpura (HSP) in France, January 1, 2015, to March 31, 2023children with HSP
- Participants
- 9,790 participants
- Exposure
- HSP incidence before vs after implementation and relaxation of COVID-19 nonpharmaceutical interventions (NPIs)
- Outcome
- Monthly incidence of HSP per 100 000 children; estimated percentage of HSP incidence potentially associated with 14 common seasonal pathogens
Methodological detailsinterrupted time-series analysis, national hospital-based surveillance system, quasi-Poisson regression
- Interrupted time-series analysis
- National hospital-based surveillance system
- quasi-Poisson regression
Main finding
As reported in the abstract
- Change in HSP incidence after implementation of NPIs (March 2020): 95% CI, −66.6% to −40.6%; P < .001
- −53.6%
- Change in HSP incidence after relaxation of NPIs (April 2021): 95% CI, 28.0%-46.3%; P < .001
- 37.2%
- HSP incidence potentially associated with Streptococcus pneumoniae: 95% CI, 22.3%-52.3%; P < .001
- 37.3%
- HSP cases associated with Streptococcus pyogenes: 95% CI, 16.7%-34.4%; P < .001
- 25.6%
- HSP cases associated with human rhino enterovirus: 95% CI, 3.8%-30.4%; P = .01
- 17.1%
Observational data: associations, not effects.
Original publication
Common Seasonal Pathogens and Epidemiology of Henoch-Schönlein Purpura Among Children. JAMA Netw Open. Published 1 April 2024. doi:10.
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