Regional differences in clinical manifestations of antisynthetase syndrome: a comparison between Asian and European cohorts
Authors' conclusion
These results suggest that regional differences may exist in the clinical manifestations of ASyS, particularly in ILD prevalence, which may be linked to the underlying distribution of anti-aminoacyl transfer RNA synthetase antibody subtypes.
Study context
- Population
- Patients with antisynthetase syndrome (ASyS) at Yokohama City University Hospital, 2010–2024; published cohorts from PubMed, January 2010 to December 2024male-to-female 13:35
- Participants
- 48 patients
- Exposure
- Japanese ASyS cohort vs previously published Asian and European cohorts
- Yokohaman = 48
- Outcome
- Clinical features of the Yokohama ASyS cohort
Methodological detailsretrospective chart review, single-centre, univariate analysis, comparison with previously published cohorts
- Retrospective chart review
- Single-centre
- Univariate analysis
- Comparison with previously published cohorts
Main finding
As reported in the abstract
- Mean age at onset (years)
- 56.5 ± 14.0
- Anti-Jo1 antibody prevalence
- 35%
- Interstitial lung disease (ILD)
- 97%
- Muscle weakness
- 52%
- Gottron's sign (most frequent skin involvement)
- 73%
- Mechanic's hands
- 65%
- Periungual erythema
- 40%
Observational data: associations, not effects.
Further findings
Asian vs European cohorts (literature review)
- Asian cohorts, including ours, tend to have higher rates of ILD complications and a lower prevalence of anti-Jo1 antibodies than European cohorts
Yokohama vs other Japanese and Asian cohorts
- Rates of Raynaud's phenomenon, muscle weakness and malignant complications nearly identical; slight differences in skin manifestations
European cohort clinical features
- Raynaud's phenomenon
- 39%
- Muscle weakness
- 85%
- Anti-Jo1 antibody positivity
- 83%
- ILD
- 68%
- Mechanic's hands
- 31%
Original publication
Regional differences in clinical manifestations of antisynthetase syndrome: a comparison between Asian and European cohorts. Arthritis Res Ther. Published 20 February 2026. doi:10.
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