Rheumatoid arthritis (RA)-risk synovium exhibits DNA damage coupled with impaired DNA repair in fibroblasts
Authors' conclusion
Our findings reveal persistent DNA damage in the preclinical phase of RA in both synovial tissue and fibroblasts, suggesting a role in disease progression.
Study context
- Population
- Synovial tissue and synovial fibroblasts from RA patients and individuals at risk of developing RA
- Comparison
- RA-risk individuals and RA patients vs control individuals
- Outcome
- Cellular DNA damage (γH2AX immunofluorescence) and DNA repair capacity (qPCR for DNA repair proteins) in synovial tissue and fibroblasts
Methodological detailssynovial biopsies, in vitro
- Synovial biopsies
- In vitro
Main finding
As reported in the abstract
- DNA damage present in synovial fibroblasts and T cells during the preclinical, RA-risk phase
- Cultured synovial fibroblasts from RA-risk and RA: increased DNA damage and reduced DNA repair capacity vs control
- Senolytic drugs partially restored DNA damage repair capacity in RA and RA-risk synovial fibroblasts in vitro
Original publication
RA-risk synovium exhibits DNA damage coupled with impaired DNA repair in fibroblasts. RMD Open. Published 22 January 2026. doi:10.
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