Lupus & antiphospholipid syndrome
Pulmonary function, functional capacity and physical activity in patients with SLE: a cross-sectional study
Authors' conclusion
Pulmonary function, exercise capacity and physical activity levels were reduced in patients with SLE compared with healthy controls. In addition, pulmonary function parameters were associated with disease duration and exercise capacity, highlighting the importance of early evaluation of respiratory function in patients with SLE.
Study context
- Population
- Patients with SLE and healthy controls25 patients with SLE and 25 healthy controls
- Participants
- 25 vs 25
- Exposure
- Patients with SLE and healthy controls
- SLEn = 25
- HEALTHY CONTROLSn = 25
- Outcome
- Forced vital capacity (FVC)
Main finding
As reported in the abstract
- SLE vs HEALTHY CONTROLS: P = 0.03
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Forced expiratory volume in 1 s (FEV1)Significantly lower with SLE | P = 0.01 |
| MVVSignificantly lower with SLE | P < 0.001 |
| 6MWT distance and GPAQ total scoreReduced with SLE | P < 0.01 |
| FEV₁/FVC ratioNo difference | P = 0.75 |
| Peak expiratory flowNo difference | P = 0.32 |
| PSQINo difference | P = 0.27 |
| FSSNo difference | P = 0.26 |
Correlations in patients with SLE
- Maximal voluntary ventilation (MVV) with disease duration (moderate negative correlation), r
- −0.585
- MVV with exercise capacity (moderate positive correlation), r
- 0.618
- FEV₁ with exercise capacity (borderline positive association), r
- 0.384
Original publication
Pulmonary function, functional capacity and physical activity in patients with SLE: a cross-sectional study. Lupus Sci Med. Published 2 November 2026. doi:10.
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