Lupus & antiphospholipid syndrome
Comorbidity burden and its impact on physical functioning and activities of daily living in patients with systemic lupus erythematosus
Authors' conclusion
Comorbidity burden is independently associated with poorer physical functioning and ADLs performance in people with SLE.
Study context
- Population
- Consecutive patients with systemic lupus erythematosus (SLE)consecutive patients with SLE
- Participants
- 240 patients
- Outcome
- Comorbidity burden (ACCI and RDCI scores)
Methodological detailsconsecutive patients, multivariate linear regression models adjusted for potential demographic and clinical confounders
- Consecutive patients
- Multivariate linear regression models adjusted for potential demographic and clinical confounders
Main finding
As reported in the abstract
ACCI score, median (IQR)
2
1–3
Rheumatic Disease Comorbidity Index (RDCI) score, median (IQR)
0
0–2
Observational data: associations, not effects.
Further findings
Association of higher ACCI scores with physical function and ADLs
- Impaired dexterity
- P < 0.001
- Reduced grip strength, across all models
- P < 0.05
- Higher Disabilities of the Arm, Shoulder, and Hand (DASH) scores and poorer scores in the “Physical Health” and “Pain” domains, after adjustment for pain intensity and fibromyalgia
- P < 0.05
- Multivariate analysis
Association of higher RDCI scores with physical function and ADLs
- Impaired dexterity
- P < 0.01
- Higher DASH scores in three models
- P < 0.05
- Poorer scores in the “Physical Health” domain across all models
- Multivariate analysis
Original publication
Comorbidity burden and its impact on physical functioning and activities of daily living in patients with systemic lupus erythematosus. Rheumatology (Oxford). Published 2 November 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →