Lupus & antiphospholipid syndrome
Total iron binding capacity: an independent predictor of prognosis for pulmonary arterial hypertension in systemic lupus erythematosus
Authors' conclusion
SI was negatively correlated with WHO-FC, and positively correlated with 6MWD and TAPSE. Furthermore, TIBC was associated with improved outcomes of patients with SLE-PAH, which could be an independent predictor of prognosis.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE)-associated PAH (SLE-PAH), excluding other factors that might lead to PAH; assessed every 1–3 months, followed up for 6 months
- Participants
- 29 patients
- Outcome
- Improvement, defined as decline in the grade of risk stratification at the endpoint (otherwise unimproved)
- Follow-up
- 6 months
Methodological detailsunivariate logistic regression, correlation analyses
- Univariate logistic regression
- Correlation analyses
Main finding
As reported in the abstract
Primary outcomes improved (patients)
12
Total iron binding capacity (TIBC) associated with improved primary outcomes, OR
12.00
95% CI 1.90–75.72
Observational data: associations, not effects.
Further findings
Correlations of serum iron (SI) with World Health Organization functional class (WHO-FC), 6MWD and tricuspid annular plane systolic excursion (TAPSE)
- SI vs WHO-FC, r (p = 0.028)
- −0.409
- SI vs 6MWD, r (p = 0.021)
- 0.427
- SI vs TAPSE, r (p = 0.037)
- 0.388
Iron parameters at baseline
- Patients with decreased TIBC
- 48%
- Mean serum ferritin higher than normal
Original publication
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