Lupus & antiphospholipid syndrome
State of current management of the heightened risk for atherosclerotic cardiovascular events in an established cohort of patients with lupus erythematosus
Authors' conclusion
Patients with CLE-only or CLE+SLE are undertreated compared with the new guidelines and, accordingly, they experience a significant burden of ASCVD events.
Study context
- Population
- UPenn Longitudinal Lupus Cohort of patients with CLE, without or with concurrent SLE, with full access to medical recordsLE-ASCVD Study Cohort
- Participants
- 370 participants
- Exposure
- CLE-only vs CLE+SLE
- Outcome
- Current cardiovascular management in light of new LE-specific ASCVD guidelines
Methodological detailssingle-centre longitudinal cohort
- Single-centre longitudinal cohort
Main finding
As reported in the abstract
Cardiovascular risk management vs new guidelines
- Designated primary-care physician
- 336 out of 370 (90.8%)
- Most recent low-density lipoprotein (LDL) above goal
- 249 out of 370 (67.3%)
- Hypertension
- Two-hundred sixty-six (71.9%)
- Hypertension undertreated or untreated
- 198 out of 266 (74.4%)
- Current smokers without documented cessation counselling or referrals
- 51 out of 63 (81.0%)
Observational data: associations, not effects.
Further findings
Clinically meaningful discordance between 3 atherosclerotic cardiovascular disease (ASCVD) risk estimation methods (ACC-ASCVD Risk Estimator Plus, QRisk3, lupus erythematosus (LE) risk categories)
- Patients qualifying for online estimators
- 278
- Discordance
- 169 out of 278 (60.8%)
Documented ASCVD event rate · first 10 years after enrolment
- ASCVD event rate
- 13.5% (95% CI 8.9%, 17.9%)
- Similar between CLE-only and CLE+SLE
- Average age at enrolment 47 years; preponderance of women
Original publication
State of current management of the heightened risk for atherosclerotic cardiovascular events in an established cohort of patients with lupus erythematosus. Lupus Sci Med. Published 21 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →