Psychosocial Burden Predicts Sustained Remission in Early Rheumatoid Arthritis: Unraveling the Complex Interplay of Well‐Being and Disease Activity
Authors' conclusion
Suboptimal psychosocial well-being and negative illness perceptions predicted lower probability of sustained remission in an early RA cohort.
Study context
- Population
- Patients with early RA in the Care in Early RA trial287 in remission at week 16
- Participants
- 231 vs 56
- Comparison
- Low vs high psychosocial burden among patients in DAS28-CRP remission at week 16
- Low psychosocial burdenn = 231
- High psychosocial burdenn = 56reference
- Primary endpoint
- Sustained remission: continued DAS28-CRP <2.6 from weeks 16 to 104
- Follow-up
- Weeks 16 to 104
Methodological detailslogistic regression, latent profile analysis, Cox proportional hazards regression, cross-lagged panel models
- Logistic regression
- Latent profile analysis
- Cox proportional hazards regression
- Cross-lagged panel models
Primary result
As reported in the abstract
Predictors of sustained DAS28-CRP remission
- Sustained remission associated with higher SF-36 scores and less passive coping at baseline
- Sustained remission associated with higher SF-36 scores and more positive Illness Perception Questionnaire (IPQ-R) outcomes at week 16
Further findings
| Outcome | Low psychosocial burden | High psychosocial burden | HR for first loss of remission (CI) | |
|---|---|---|---|---|
| Time to first loss of remission by psychosocial burden subgroup, patients in DAS28-CRP remission at week 16 (n = 287)Low psychosocial burden group retained remission longer · subgroups identified by Latent Profile Analysis | n = 231 of 287 | n = 56 of 287 | 0.51 (0.35–0.73) | |
| 0.20.5125HR for first loss of remission (log scale) |
Original publication
Psychosocial Burden Predicts Sustained Remission in Early Rheumatoid Arthritis: Unraveling the Complex Interplay of Well‐Being and Disease Activity. Arthritis Care Res (Hoboken). Published 28 November 2022. doi:10.
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