Higher skin autofluorescence in individuals at risk for rheumatoid arthritis: results from a large population based cohort
Authors' conclusion
Our results indicate that ACPA-positive individuals with RA risk have elevated SAF levels, which is regarded as a non-invasive marker for oxidative stress and a possible indicator for development of cardiovascular disease.
Study context
- Population
- Participants of the Dutch Lifelines Cohort Study with baseline skin autofluorescence (SAF) and anticitrullinated protein antibodies (ACPA) levels available
- Participants
- 17,346 participants
- Exposure
- ACPA-positive groups and defined rheumatoid arthritis (RA) vs ACPA-negative controls
- ACPA-negative controlsn = 17,211reference
- ACPA-positive without joint complaintsn = 49
- ACPA-positive RA riskn = 31
- Defined RAn = 52
- Outcome
- Skin autofluorescence (SAF) levels
- Follow-up
- Baseline
Methodological detailspopulation-based cohort, multinomial regression
- Population-based cohort
- Multinomial regression
Main finding
As reported in the abstract
SAF levels vs controls
Odds ratio
2.04
P = 0.034
ACPA-positive RA risk
Odds ratio
3.10
P < 0.001
Defined RA
Odds ratio
1.07
P = 0.875
ACPA-positive without joint complaints
Observational data: associations, not effects.
Further findings
| Outcome | OR | P value |
|---|---|---|
| SAF levels, age-adjustedDefined RA vs ACPA-negative controls | 2.09 | P = 0.011 |
| SAF levels, age-adjustedACPA-positive RA risk vs ACPA-negative controls · effect comparable | 2.09 |
SAF levels, age-adjusted
- Difference in defined RA remained significant after adjusting for smoking status, renal function or HbA1c
Original publication
Higher skin autofluorescence in individuals at risk for rheumatoid arthritis: results from a large population based cohort. Clin Exp Rheumatol. Published 25 November 2022. doi:10.
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