Adenosine metabolic signature in circulating CD4+ T cells predicts remission in rheumatoid arthritis
Main finding · Baseline predictors of DAS28-CRP remissionResult — go to the resultAUC for early remission 0.92 vs 0.67Authors' conclusion
Adenosine signalling is important in the achievement of early remission with MTX in RA
Study context
- Population
- Treatment-naive patients with early rheumatoid arthritis (RA) commencing methotrexate (MTX); purified circulating CD4+ T cells
- Participants
- 68 patients
- Exposure
- Patients achieving DAS28-CRP remission vs those not achieving remission at 6 months on MTX
- Outcome
- Predictors of DAS28-CRP remission (<2.4)
- Follow-up
- 6 months
Methodological detailsbiomarker study, logistic regression and linear modelling
- Biomarker study
- Logistic regression and linear modelling
Main finding
Baseline predictors of DAS28-CRP remission
AUC for early remission
0.92 vs 0.67
P = 0.001
By group
As reported in the abstract
Observational data: associations, not effects.
Original publication
Adenosine metabolic signature in circulating CD4+ T cells predicts remission in rheumatoid arthritis. RMD Open. Published 17 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →