Association between rapid and sustained remission and clinician- and patient-reported outcomes in patients with rheumatoid arthritis: post hoc analysis of data from the SELECT-COMPARE study
Authors' conclusion
Remission is a key outcome in RA; this study showed that achieving rapid remission, as well as reducing time to achieving remission, was associated with less pain and fatigue, and better physical functioning and quality of life over 5 years. Similarly, increasing time spent in sustained remission correlated with sustained improvement in CRO/PROs.
Study context
- Population
- Patients with moderately-to-severely active rheumatoid arthritis (RA) receiving upadacitinib or adalimumab in SELECT-COMPARE and its open-label long-term extensionmean disease duration 8.2 ± 7.8 years
- Participants
- 865 patients
- Comparison
- Rapid remission vs no rapid remission
- Rapid remissionn = 247
Methodological detailspooled data, open-label long-term extension (up to 5 years), multivariate regression adjusted for baseline covariates
- Pooled data
- Open-label long-term extension (up to 5 years)
- Multivariate regression adjusted for baseline covariates
Primary result
As reported in the abstract
Association of rapid remission with CRO/PROs · up to 5 years
Rapid remission
28%
247
- Odds of achieving minimal clinically important differences (MCIDs) in most PROs (aOR range)
- 2.2-5.6
- Odds of achieving normative values in most PROs (aOR range)
- 1.6-9.8
Further findings
Time to remission
- Decrease in likelihood of achieving MCIDs or normative values per month delay in remission, on average
- 13%
Time in sustained remission
- Increasing time in sustained remission associated with long-term improvement in CRO/PROs
Original publication
Association between rapid and sustained remission and clinician- and patient-reported outcomes in patients with rheumatoid arthritis: post hoc analysis of data from the SELECT-COMPARE study. Arthritis Res Ther. Published 13 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →