Lupus & antiphospholipid syndrome
Protective effect of antimalarials on the most frequently affected damage domains in SLE: Data from a multiethnic Latin American cohort
Authors' conclusion
AM use is independently associated with a lower probability of overall, renal, and neuropsychiatric damage accrual.
Study context
- Population
- Patients with SLE from the GLADEL cohortmedian follow-up 48.5 months
- Participants
- 850 patients
- Exposure
- AM users vs non-users
- AM usersn = 419
- Non-usersn = 431reference
- Outcome
- New damage (≥1 point increase in SDI since cohort entry), overall and in the most frequently affected domains
Methodological detailsmultiethnic Latin American cohort (GLADEL), matched for age, sex, ethnicity and baseline SDI (stratified random sampling), propensity score matching
- Multiethnic Latin American cohort (GLADEL)
- Matched for age, sex, ethnicity and baseline SDI (stratified random sampling)
- Propensity score matching
Main finding
As reported in the abstract
Patients accruing new damage (≥1 point SDI increase) at follow-up · median follow-up 48.5 (IQR 19.3, 69.0) months
- Antimalarials (AMs) users vs non-users: P = 0.028
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Protective effect of antimalarials on the most frequently affected damage domains in SLE: Data from a multiethnic Latin American cohort. Lupus. Published 25 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →