Lupus & antiphospholipid syndrome
Expression levels of miR-146a-5p, miR-155-5p and the pro-inflammatory cytokine IL-8 in pregnant women with anti-phospholipid syndrome
Authors' conclusion
miR-146a-5p significantly higher among APS group. IL-8 significantly more predominates among APS group. Alterations in miRNA expression are involved in thrombosis associated pregnancy complications.
Study context
- Population
- Pregnant women with anti-phospholipid syndrome (APS) and healthy pregnant controls
- Participants
- 50 vs 50
- Comparison
- Pregnant women with APS vs healthy pregnant women
- APSn = 50
- Controln = 50reference
- Outcome
- Expression levels of miR-146a-5p, miR-155-5p (qPCR) and IL-8 (enzyme-linked immunosorbent assay (ELISA))
Main finding
As reported in the abstract
miR-146a-5p expression
| Group | Value | AUC | Sensitivity | Specificity |
|---|---|---|---|---|
| APS | mean 0.95 (SD 0.7) | 0.813 | 66% | 86% |
| Control | mean 0.27 (SD 0.4) |
Value
APSmean 0.95 (SD 0.7)
Controlmean 0.27 (SD 0.4)
AUC
APS0.813
Control— not stated in the abstract
Sensitivity
APS66%
Control— not stated in the abstract
Specificity
APS86%
Control— not stated in the abstract
- APS vs Control: CI 0.44–0.90; 0.01
Observational data: associations, not effects.
Further findings
| Outcome | APS | ControlMean | Estimate | P value |
|---|---|---|---|---|
| miR-155-5p expression | mean 0.57 (SD 1.0) | 0.48 (SD 0.7) | (CI −0.25-0.43) | 0.60 |
| AUC | 0.582 | — not stated in the abstract | ||
| Sensitivity | 92% | — not stated in the abstract | ||
| Specificity | 40% | — not stated in the abstract | ||
| IL-8 levels | mean 6.11 (SD 1.2) | 5.19 (SD 0.5) | (CI −0.36- 0.52) | P < 0.001 |
— not stated in the abstract
Original publication
Expression levels of miR-146a-5p, miR-155-5p and the pro-inflammatory cytokine IL-8 in pregnant women with anti-phospholipid syndrome. Lupus. Published 25 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →