Lupus & antiphospholipid syndrome
Association of systemic lupus erythematosus with clinical and psychosocial outcomes, health care resource utilization and expenditures: A nationally representative US-based analysis
Authors' conclusion
Poor physical HRQoL, increased cognitive and functional limitations, and psychological distress are common among patients with SLE.
Study context
- Population
- US 2017–2022 Medical Expenditure Panel Survey respondents
- Exposure
- Systemic lupus erythematosus (SLE) vs matched individuals without SLE
- Outcome
- Clinical and psychosocial outcomes
Methodological detailsUS population-based, Medical Expenditure Panel Survey 2017-2022, matched (eight patients without SLE per patient with SLE) on survey year, age and sex, multivariable regression
- US population-based
- Medical Expenditure Panel Survey 2017-2022
- Matched (eight patients without SLE per patient with SLE) on survey year, age and sex
- Multivariable regression
Main finding
As reported in the abstract
SLE vs Without SLEAdjusted odds ratio (95% CI)
Pain interference with activities
1.998(1.372–2.909)
Fair to poor physical health status
3.141(1.993–4.949)
Cognitive limitations
2.665(1.465–4.849)
Functional limitations
2.594(1.646–4.089)
Social limitations
2.227(1.437–3.451)
Psychological distress
2.023(1.447–2.827)
Observational data: associations, not effects.
Further findings
Average annual healthcare expenditures (unadjusted)
P < 0.0001
Average annual healthcare expenditures (adjusted)
P < 0.05
| Outcome | Adjusted annualized event rate ratio | P value |
|---|---|---|
| Healthcare resource utilizationOutpatient visits | 2.603 | P < 0.05 |
| Healthcare resource utilizationOffice-based visits | 1.447 | P < 0.05 |
| Healthcare resource utilizationED visits | 1.518 | P < 0.05 |
Average annual healthcare expenditures (unadjusted)
- Consistent across each healthcare resource component
Original publication
Association of systemic lupus erythematosus with clinical and psychosocial outcomes, health care resource utilization and expenditures: A nationally representative US-based analysis. Lupus. Published 25 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →