Lupus & antiphospholipid syndrome
Prevalence, risk factors and echocardiographic predictors of pulmonary hypertension in systemic lupus erythematosus: towards a screening protocol
Authors' conclusion
In our cohort, 7.96% of patients with SLE had an intermediate or high PH probability. By RHC, six patients (2.99%) met the ESC/European Respiratory Society criteria for PH and four (1.99%) for PAH.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) who underwent transthoracic echocardiography; 88.56% women, 85.57% of Spanish origin
- Participants
- 201 patients
- Exposure
- Pulmonary hypertension (PH) vs No PH
- Outcome
- Prevalence of probable SLE-PH
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Prevalence of PH in SLE
Intermediate or high probability criteria for PH (European Society of Cardiology (ESC) 2022)
16
7.96%
SLE-PH confirmed by right heart catheterisation (RHC)
2.99%
SLE-PAH confirmed by RHC
1.99%
Observational data: associations, not effects.
Further findings
Mortality · 2-year follow-up
P = 0.002
Mean
| Outcome | PH | No PH | P value |
|---|---|---|---|
| SLICC/ACR DI (SDI), mean | 4.75 | 2.05 | P < 0.001 |
Key risk factors for PH
- Age, cardiorespiratory symptoms, serositis, anti-Ro, cardiac biomarkers and altered pulmonary function tests (PFTs)
Original publication
Prevalence, risk factors and echocardiographic predictors of pulmonary hypertension in systemic lupus erythematosus: towards a screening protocol. RMD Open. Published 8 January 2024. doi:10.
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