Lupus & antiphospholipid syndrome
Pulmonary arterial hypertension in systemic lupus erythematosus: identification of risk factors and haemodynamics characteristics in a multicentre retrospective cohort
Authors' conclusion
Our data showed that LAC+, RNP+, RP and a scleroderma pattern at NVC was indicative for patients with SLE-PAH.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) with and without pulmonary arterial hypertension (PAH)
- Participants
- 20 vs 87
- Exposure
- SLE with PAH vs SLE without PAH
- SLE-PAHn = 20
- No-PAHn = 87reference
- Outcome
- Clinical features and nailfold capillary changes associated with PAH in SLE
Methodological detailsmulticentre, case-control comparison
- Multicentre
- Case-control comparison
Further findings
LA positivity
P = 0.042
Anti-RNP positivity
P = 0.035
Mucocutaneous involvement
P = 0.024
Central nervous system involvement
P = 0.046
RP
P < 0.001
Scleroderma pattern at NVC · NVC performed in nine patients with PAH and in controls
P < 0.001
Raynaud's phenomenon (RP) as predictor of PAH in SLE
| OR (CI) | ||
|---|---|---|
| RP | 3.8 (0.9–14.8) | |
| 0.050.21520Odds ratio (log scale) |
Anti-Sm, anti-Ro, anti-La, aCL and anti-beta2GPI antibodies
- No differences were observed
Capillary density and giant capillaries at nailfold videocapillaroscopy (NVC)
- SLE-PAH showed lower capillary density and higher frequency of giant capillaries
Sex, age and disease duration
- All patients with SLE-PAH were women; age and disease duration not different from no-PAH
Original publication
Pulmonary arterial hypertension in systemic lupus erythematosus: identification of risk factors and haemodynamics characteristics in a multicentre retrospective cohort. Lupus Sci Med. Published 12 June 2025. doi:10.
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