Prevalence of tissue transglutaminase antibodies and IgA deficiency are not increased in juvenile idiopathic arthritis: a case-control study
Authors' conclusion
Using the largest JIA cohort to date to investigate prevalence of celiac antibodies, the prevalence of positive tTG IgA was 0.8% and of IgA deficiency was 1.2%. The results did not demonstrate a higher prevalence of abnormal tTG IgA in JIA.
Study context
- Population
- Patients with Juvenile Idiopathic Arthritis (JIA) followed in two large academic medical centers, and controls
- Participants
- 808 vs 140
- Comparison
- JIA cases vs controls
- JIAn = 808
- Controlsn = 140reference
- Outcome
- Prevalence of IgA deficiency and tissue transglutaminase (tTG) IgA
Methodological detailstwo large academic medical centers
- Two large academic medical centers
Main finding
As reported in the abstract
IgA deficiency
JIA
1.2%
Controls
0
events
P = 0.373
Observational data: associations, not effects.
Further findings
| Outcome | JIA | Controls | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| tTG IgA ≥ 4u/mL (IgA deficient subjects excluded) | 2% | 3.6% | 0.5 (0.1–1.4) | P = 0.216 | |
| tTG IgA > 10u/mL (IgA deficient subjects excluded) | 0.8% | 1.4% | 0.5 (0.1–2.9) | P = 0.627 | |
| 0.10.31310Odds ratio (log scale) |
Original publication
Prevalence of tissue transglutaminase antibodies and IgA deficiency are not increased in juvenile idiopathic arthritis: a case-control study. Pediatr Rheumatol Online J. Published 5 October 2023. doi:10.
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