Skin manifestations help identifying different phenotypes of paediatric SAPHO syndrome
Authors' conclusion
our data suggest that two different skin phenotypes may be identified in SAPHO: the first is constituted by prepuberal females with PPP and a prevalent osteoarticular involvement, while the second by puberal males with a difficult-to-treat acne-HS.
Study context
- Population
- Paediatric SAPHO patients followed 2001–2022 at the Unit for Autoinflammatory diseases, Gaslini Hospital (Eurofever database)
- Participants
- 14 patients
- Exposure
- Acne-HS vs Palmo-Plantar Pustulosis (PPP) skin phenotype
- Acne-HSn = 8
- PPPn = 6
- Outcome
- Disease presentation and outcome by skin phenotype
Methodological detailssingle-centre, with literature review
- Single-centre
- With literature review
Main finding
As reported in the abstract
Acne-HS: males
7 of 8
Observational data: associations, not effects.
Further findings
Literature review
- Confirmed association males-acne-puberal age and female-PPP-prepuberal age
Original publication
Skin manifestations help identifying different phenotypes of paediatric SAPHO syndrome. Semin Arthritis Rheum. Published 5 October 2023. doi:10.
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