Predictors of persistent active disease and the longitudinal development of organ damage, patient-reported outcomes and autoantibodies in long-term juvenile dermatomyositis
Authors' conclusion
After a median of 21.7 years from symptom onset, the majority of JDM patients still had active disease. Higher organ damage and disease activity at the initial visit predicted persistent active disease at follow-up.
Study context
- Population
- Patients with juvenile dermatomyositis (JDM) after long-term follow-up65% female
- Participants
- 40 patients
- Outcome
- Persistent active disease (updated PRINTO criteria) and its predictors
- Follow-up
- Visit 2
Methodological detailstwo time points (visits 1 and 2)
- Two time points (visits 1 and 2)
Main finding
As reported in the abstract
Active disease (PRINTO)
Active disease (PRINTO)
53%
Observational data: associations, not effects.
Further findings
Impaired physical function (CHAQ/HAQ>0) · visit 2
- Impaired physical function (CHAQ/HAQ>0)
- 40%
Organ damage (MDItotal≥1) · visit 2
- Organ damage (MDItotal≥1)
- 95%
Myositis specific or associated antibodies · visit 2
- Myositis specific or associated antibodies
- 33%
Disease activity (Juvenile DermatoMyositis Activity Index (JDMAI)) · visit 2
- Low
- 24%
- Moderate
- 8%
- High
- 3%
Organ damage and disease activity, visit 1 vs visit 2
- No significant differences between visits
Median disease duration from symptom onset
- Visit 1 (years)
- 15.1 (2.0-34.6)
- Visit 2 (years)
- 21.7 (7.6-42.7)
Original publication
Predictors of persistent active disease and the longitudinal development of organ damage, patient-reported outcomes and autoantibodies in long-term juvenile dermatomyositis. RMD Open. Published 5 June 2025. doi:10.
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