Glucocorticoid tapering early in the course of juvenile SLE: association with lupus low disease activity state and outcomes
Authors' conclusion
Successful GC tapering is feasible and does not increase the risk of flares during the early disease phase. However, flares are common and adversely affect GC tapering.
Study context
- Population
- Children with moderate-to-severe juvenile SLE, 2012–2022
- Participants
- 80 children
- Exposure
- Successful glucocorticoid (GC) tapering within the first year vs no successful tapering
- Successful taperingn = 50
- Outcome
- Successful GC tapering and risk of flares
- Follow-up
- First year of treatment
Methodological detailslinear mixed-effects model, Cox regression, logistic regression
- Linear mixed-effects model
- Cox regression
- Logistic regression
Main finding
As reported in the abstract
Successful GC tapering within the first year
Successful tapering
62.5%
50
- Flares observed
- 23 (28.8%)
- GC tapering trajectories similar based on flare observations
- P > 0.05
Observational data: associations, not effects.
Further findings
| Outcome | OR | P value |
|---|---|---|
| Positive anti-dsDNA at twelfth month and odds of flares | 4.8 | P = 0.008 |
Initial GC dose in patients without flares
- Patients without flares received significantly higher initial GC doses
- P = 0.046
Childhood lupus low disease activity state (cLLDAS) achievement · twelfth month
- cLLDAS achieved
- 40 (50%)
- cLLDAS achievement not protective against future flares
Original publication
Glucocorticoid tapering early in the course of juvenile SLE: association with lupus low disease activity state and outcomes. Lupus Sci Med. Published 27 May 2025. doi:10.
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