Predictive Value of Magnetic Resonance Imaging in Patients With Juvenile Idiopathic Arthritis in Clinical Remission
Authors' conclusion
MRI-detected subclinical inflammation was present in a large proportion of patients with JIA despite clinical remission.
Study context
- Population
- Patients with clinically inactive juvenile idiopathic arthritis (JIA) who underwent CE-MRI of a previously affected joint
- Participants
- 90 patients
- Exposure
- Subclinical synovitis on magnetic resonance imaging (MRI) vs no residual synovitis on MRI
- Subclinical synovitisn = 59
- No residual synovitisn = 31reference
- Outcome
- Prevalence of subclinical synovitis on MRI in JIA in clinical remission, and its predictive value for disease flare and joint deterioration
Methodological detailscontrast-enhanced MRI, multivariable regression analysis
- Contrast-enhanced MRI
- Multivariable regression analysis
Main finding
As reported in the abstract
Prevalence of subclinical synovitis on MRI
Subclinical synovitis
59 (65.5%) of 90
Bone marrow edema
42 (46.7%) of 90
Observational data: associations, not effects.
Further findings
Disease flare during follow-up
P = 0.002
Radiographic damage progression (54 patients with baseline and follow-up radiographs)
| HR | P value | |
|---|---|---|
| Bone marrow edemaMultivariable analysis | 4.40 | P = 0.045 |
| >17 years oldMultivariable analysis | 3.51 | P = 0.04 |
| Outcome | HR | P value |
|---|---|---|
| Disease flare during follow-up | 2.45 | P = 0.003 |
- Disease flare during follow-up — Disease flare, all patients
- 57 of 90 (63.3%)
- Radiographic damage progression (54 patients with baseline and follow-up radiographs) — Radiographic damage progression
- 17 (31.5%) of 54
- Disease flare during follow-up: best predictor of disease flare on multivariable regression analysis
Original publication
Predictive Value of Magnetic Resonance Imaging in Patients With Juvenile Idiopathic Arthritis in Clinical Remission. Arthritis Care Res (Hoboken). Published 20 September 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →