Lupus & antiphospholipid syndrome
Potential involvement of IL-40 in kidney disease associated to systemic lupus erythematosus
Authors' conclusion
To the best of our knowledge this is the first demonstration of IL-40 expression at kidney level in SLE.
Study context
- Population
- Patients with Systemic lupus erythematosus (SLE), including SLE-associated nephritis, and controls32 SLE, 21 controls
- Comparison
- SLE vs controls
- Controlsn = 21reference
- Outcome
- Expression of IL-40 in SLE and LN
Methodological detailscase-control, ELISA, flow cytometry, in vitro rIL-40 stimulation of peripheral blood mononuclear cells (PBMC), kidney biopsy immunofluorescence
- Case-control
- ELISA
- Flow cytometry
- In vitro rIL-40 stimulation of PBMC
- Kidney biopsy immunofluorescence
Main finding
As reported in the abstract
IL-40 expression in serum, urine, cells and kidney tissue
- Serum IL-40 levels show a decreasing trend in SLE with lupus nephritis (LN) vs SLE without LN and controls
- No differences between SLE and controls in urinary IL-40 levels
- No differences between SLE and controls in % of CD3+IL40+, CD19+IL40+ and CD14+IL40+ cells
- No differences between SLE and controls in pro-inflammatory cytokine production by PBMC stimulated with rIL-40
- IL-40 expression markedly increased in kidney tissue from LN patients, with significant increase of IL40+ cells in LN samples vs controls (quantification analysis)
Original publication
Potential involvement of IL-40 in kidney disease associated to systemic lupus erythematosus. Lupus. Published 18 July 2025. doi:10.
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