Lupus & antiphospholipid syndrome
Plasma proteomics for risk prediction and identification of novel drug targets in systemic lupus erythematosus
Authors' conclusion
The SLE protein risk score had a good predictive performance for new-onset SLE in women. ITGAV, TNFRSF4, CXCL10 and CD207 were potential treatment targets for SLE.
Study context
- Population
- Women from the UK Biobankwomen, UK Biobank
- Participants
- 28,220 women
- Exposure
- Systemic lupus erythematosus (SLE) protein risk score vs clinical risk factors and polygenic risk score for predicting new-onset SLE
- Outcome
- New-onset SLE (prediction performance, C-index)
- Follow-up
- Median 13.3 years
Methodological detailsplasma proteomics, random split into training (70%) and testing (30%) sets, Mendelian randomisation (causal association)
- Plasma proteomics
- Random split into training (70%) and testing (30%) sets
- Mendelian randomisation (causal association)
Main finding
As reported in the abstract
Prediction of new-onset SLE, C-index (testing set)
| Group | C-index | 95%CI |
|---|---|---|
| Protein risk score | 0.801 | 0.715, 0.887 |
| Clinical risk factors | 0.706 | 0.612, 0.800 |
| Polygenic risk score | 0.638 | 0.555, 0.721 |
| Clinical risk factors + protein risk score | 0.827 |
C-index
Protein risk score0.801
Clinical risk factors0.706
Polygenic risk score0.638
Clinical risk factors + protein risk score0.827
95%CI
Protein risk score0.715, 0.887
Clinical risk factors0.612, 0.800
Polygenic risk score0.555, 0.721
Clinical risk factors + protein risk score— not stated in the abstract
Observational data: associations, not effects.
Further findings
- ITGAV, TNFRSF4, CXCL10 and CD207 causally associated with SLE; TNFRSF4 and CXCL10 developed as drug targets for cancer and autoimmune diabetes
- 22 proteins enriched in cytokine-cytokine receptor interaction, inflammatory and immune response; TNF, CD80 and LGALS9 key proteins in network
Original publication
Plasma proteomics for risk prediction and identification of novel drug targets in systemic lupus erythematosus. Rheumatology (Oxford). Published 30 January 2025. doi:10.
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