Lupus & antiphospholipid syndrome
Medication-related hospitalisations in patients with SLE
Authors' conclusion
Forty per cent of SLE hospitalisations were medication-related, while half were potentially preventable/ameliorable. Renal involvement, polypharmacy, prednisone and immunosuppressant use were associated with hospitalisation related to an ADE, highlighting a vulnerable group.
Study context
- Population
- Patients with SLE in a large prospective longitudinal cohort admitted to tertiary hospitals, 2015–2020 (91% female; median age 38 years)
- Participants
- 45 patients68 hospitalisations
- Outcome
- Medication-related hospitalisations (ADEs and medication non-adherence) and their preventability
Methodological detailslongitudinal, tertiary hospitals, independent adjudication (Leape and Bates method), logistic regression with generalised estimating equations
- Longitudinal
- Tertiary hospitals
- Independent adjudication (Leape and Bates method)
- Logistic regression with generalised estimating equations
Main finding
As reported in the abstract
Hospitalisations with ≥1 contributing ADE
20
29%
Adverse drug events (ADEs) preventable/ameliorable
11 of 23
48%
Hospitalisations with SLE flare associated with medication non-adherence
7
10%
Observational data: associations, not effects.
Further findings
Factors associated with ADE-related (vs non-ADE) hospitalisation, adjusted for age and sex
| aOR (95% CI) | ||
|---|---|---|
| Current prednisone use | 3.7 (1.1–13.0) | |
| ≥1 current immunosuppressant | 11.5 (2.7–50.0) | |
| Renal involvement at SLE diagnosis | 6.5 (2.7–15.7) | |
| Polypharmacy (≥5 medications) | 11.3 (1.2–103.8) | |
| 0.050.21520Adjusted odds ratio (log scale) |
Factors associated with hospitalisation for flare related to non-adherence
| OR (95% CI) | ||
|---|---|---|
| Age at SLE diagnosis <18 years | 5.9 (1.3–26.6) | |
| 0.050.21520Odds ratio (log scale) |
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →