Fibromyalgia & musculoskeletal pain
Pharmacological interventions for early-stage frozen shoulder: a systematic review and network meta-analysis
Authors' conclusion
These results shows that IA CS and IA PRP injections are beneficial for early-stage frozen shoulder.
Study context
- Population
- Early-stage, pain predominant adhesive capsulitis (frozen shoulder)31 studies · 22 randomized controlled trials (RCTs)
- Comparison
- Pharmacological interventions vs physical therapy
- IA CSn = 340
- IA platelet-rich plasma (PRP)n = 177
- Oral NSAIDsn = 44
- IA hyaluronaten = 42
- Outcome
- Shoulder pain, shoulder function and range of movement
- Follow-up
- 12 weeks
Methodological detailsPRISMA, pairwise meta-analyses, network meta-analysis of RCTs
- PRISMA
- Pairwise meta-analyses
- Network meta-analysis of RCTs
Pooled result
As reported in the abstract
Shoulder pain and function
- IA CS (8 RCTs) showed benefit vs physical therapy for shoulder pain and function
- IA PRP (3 RCTs) showed benefit vs physical therapy for shoulder pain and function
- Oral NSAIDs (2 RCTs) did not show a benefit
- IA hyaluronate (2 RCTs) did not show a benefit
Further pooled results
Shoulder range of movement
- Only IA PRP showed benefit over physical therapy
Original publication
Pharmacological interventions for early-stage frozen shoulder: a systematic review and network meta-analysis. Rheumatology (Oxford). Published 27 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →