Lupus & antiphospholipid syndrome
Performance of the 2023 American College of Rheumatology/EULAR Classification Criteria for Antiphospholipid Syndrome in a Mexican Cohort
Authors' conclusion
In both PAPS and SAPS, the 2023 AECC have higher specificity than the 2006 RSCC. The main feature of patients with PAPS according to the 2023 AECC was thrombosis.
Study context
- Population
- Mexican cohort of patients with primary antiphospholipid syndrome (APS) (PAPS; n = 85) and secondary APS (SAPS; n = 54), and controls with nonautoimmune thrombophilia (n = 50)85 PAPS, 54 SAPS, 50 thrombophilia
- Comparison
- 2023 ACR/EULAR APS classification criteria vs 2006 revised Sapporo classification criteria
- Outcome
- Performance (sensitivity, specificity) of the 2023 AECC against clinical diagnosis as gold standard
Methodological detailscohort, clinical diagnosis as gold standard
- Cohort
- Clinical diagnosis as gold standard
Performance
As reported in the abstract
Classification performance for PAPS
| Strategy | Sensitivity | Specificity |
|---|---|---|
| 2023 AECC | 81.2% | 100.0% |
| 2006 RSCC | 88.2% | 92.0% |
Sensitivity
2023 AECC81.2%
2006 RSCC88.2%
Specificity
2023 AECC100.0%
2006 RSCC92.0%
Further findings
| Outcome | PAPS | SAPS | Thrombophilia |
|---|---|---|---|
| Fulfilment of 2023 AECC by group | 81.2% | 51.9% | 0 events |
Classification performance for SAPS
- Similar findings observed in SAPS (lower sensitivity, higher specificity of 2023 AECC vs 2006 RSCC)
Correlation of 2023 AECC score with Global APS Score (GAPSS) and Damage Index for APS (DIAPS) in PAPS
- Correlation with GAPSS (rho), P < 0.0001
- 0.621
- Correlation with DIAPS (rho), P < 0.0001
- 0.433
True positive (n = 69) vs false negative (n = 16) PAPS cases
- True positive (TP) cases had higher frequency of thrombotic manifestations and IgM aCL and IgG anti-β2-glycoprotein-I positivity
Original publication
Performance of the 2023 American College of Rheumatology/EULAR Classification Criteria for Antiphospholipid Syndrome in a Mexican Cohort. Arthritis Rheumatol. Published 4 August 2024. doi:10.
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