Lupus & antiphospholipid syndrome
Perceptions of ageing among middle-aged and older adults with SLE: a single-centre cross-sectional study
Authors' conclusion
Negative self-perception of ageing was independently associated with decreased HRQoL among middle-aged and older adults with SLE.
Study context
- Population
- Adults ≥50 years with validated SLE95.0% female
- Participants
- 80 adults
- Exposure
- Awareness of age-related change (AARC) gains and losses (self-perceptions of ageing) vs pain interference, depression, disability and frailty
- Outcome
- Associations of AARC losses and gains with pain interference, depression, frailty and disability, adjusted for age, race, ethnicity, SLE disease activity and organ damage
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Odds ratio (frailty) (95% CI)P value
AARC losses
2.09(1.30–3.37)
P < 0.01- AARC losses
- ß coefficient (pain interference) 0.94 (95% CI 0.33–1.54); P < 0.01
- AARC losses
- ß coefficient (depression) 0.67 (95% CI 0.04–1.30); P = 0.04
- AARC gains
- ß coefficient (disability) −0.07 (95% CI −0.09 to −0.02); P < 0.01
- AARC losses
- ß coefficient (disability) 0.08 (95% CI 0.03–0.12); P < 0.01
- Mean PROMIS-29 T-score, pain interference (SD 10.1)
- 54.6
- Mean PROMIS-29 T-score, depression (SD 8.5)
- 49.8
- Frail
- 29.9%
Observational data: associations, not effects.
Original publication
Perceptions of ageing among middle-aged and older adults with SLE: a single-centre cross-sectional study. Lupus Sci Med. Published 30 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →