Lupus & antiphospholipid syndrome
Perceived Stress and Prediction of Worse Disease Activity and Symptoms in a Multiracial, Multiethnic Systemic Lupus Erythematosus Cohort
Authors' conclusion
In a racially diverse sample of individuals with SLE, those who experienced an increase in stress had significantly worse disease activity and greater symptom burden at follow-up compared to those with stress levels that remained stable or declined.
Study context
- Population
- Multiracial, multiethnic systemic lupus erythematosus (SLE) cohort from the California Lupus Epidemiology Study (CLUES); 91% female, mean ± SD age 46 ± 14 years
- Participants
- 260 participants
- Exposure
- Increase in perceived stress vs stable or declining stress
- Outcome
- Physician-assessed disease activity (SLEDAI), patient-reported disease activity (Systemic Lupus Activity Questionnaire), pain (PROMIS pain interference) and fatigue (PROMIS fatigue)
- Follow-up
- Year 3 visit
Methodological detailslongitudinal, multivariable linear regression
- Longitudinal
- Multivariable linear regression
Main finding
As reported in the abstract
Adjusted longitudinal associations of increase in stress with 4 outcomes at year 3
- Increase in stress vs Stable or declined stress: P = 0.015
- Increase in stress vs Stable or declined stress: P < 0.001
- Increase in stress vs Stable or declined stress: P = 0.019
- Increase in stress vs Stable or declined stress: P < 0.001
- Adjusted for potential confounders
Observational data: associations, not effects.
Original publication
Perceived Stress and Prediction of Worse Disease Activity and Symptoms in a Multiracial, Multiethnic Systemic Lupus Erythematosus Cohort. Arthritis Care Res (Hoboken). Published 3 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →