Patient-reported outcome for physical function in idiopathic inflammatory myopathy
Authors' conclusion
PROMIS PF-20 demonstrates favourable psychometric properties including reliability, validity and responsiveness in a large cohort of myositis patients, with similar adherence in local or remotely enrolled patients.
Study context
- Population
- US patients with idiopathic inflammatory myopathies (IIM) (My PACER study)75% females
- Participants
- 120 patients
- Exposure
- Tele-research cohort vs centre-based cohort
- Outcome
- Feasibility, compliance and psychometric properties of PROMIS physical function-20 (PF-20)
Methodological detailsmulticentre, psychometric validation, centre-based cohort (CBC) randomly divided 1:1 into local and remote subcohorts, Patient-reported outcomes and self-assessments monthly for 6 months; clinician-reported outcomes at baseline and 6 months
- Multicentre
- Psychometric validation
- CBC randomly divided 1:1 into local and remote subcohorts
- Patient-reported outcomes and self-assessments monthly for 6 months; clinician-reported outcomes at baseline and 6 months
Main finding
As reported in the abstract
PROMIS PF-20 feasibility, compliance and psychometric properties
- Compliance and completion rates similar between tele-research cohort (TRC) and CBC as well as subcohorts
- Strong test-retest reliability at 1 month
- Significantly associated with all core set measures except extra-muscular global and creatine kinase, and with most symptoms, function and physical activity measures
- Concordant change with myositis response criteria and patient assessment, with a large effect size
- Patient-Reported Outcomes Measurement Information System (PROMIS) PF-20 score not associated with age, sex or race
- Similar demographics and mean PROMIS PF-20 score between cohorts
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Patient-reported outcome for physical function in idiopathic inflammatory myopathy. Rheumatology (Oxford). Published 6 February 2024. doi:10.
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