Effect modification of cancer on the association between dysphagia and mortality in early idiopathic inflammatory myopathies
Authors' conclusion
In this IIM cohort, dysphagia in non-cancer patients was not associated with increased mortality, while it was in presence of cancer, supporting effect modification of cancer on the association between dysphagia and mortality.
Study context
- Population
- Adult idiopathic inflammatory myopathies (IIM) patients with dysphagia assessment within 6 months of disease onset
- Participants
- 230 patients
- Exposure
- Dysphagia vs no dysphagia, stratified by cancer status
- Outcome
- Mortality
- Follow-up
- 5 years after cohort entry
Methodological detailsCox models stratified on cancer status, interaction model
- Cox models stratified on cancer status
- Interaction model
Main finding
As reported in the abstract
Mortality, dysphagia effect stratified by cancer status (adjusted Cox models) · 5 years
Dysphagia vs No dysphagiaHazard ratio (95% CI)
Non-cancer patients
0.5(0.2–1.5)
Cancer patients
3.1(1.0–10.2)
- Mortality rate per 100 person-years with dysphagia, without cancer
- 2.3 (95 %CI 1.0 to 4.5)
- Mortality rate per 100 person-years with dysphagia, with cancer
- 33.3 (95 %CI 16.6 to 59.5)
Observational data: associations, not effects.
Further findings
Mortality, combination of dysphagia and cancer (interaction model)
| HR (CI) | ||
|---|---|---|
| Dysphagia + cancerInteraction model | 6.4 (1.2–35.1) | |
| 0.050.21520Hazard ratio (log scale) |
Original publication
Effect modification of cancer on the association between dysphagia and mortality in early idiopathic inflammatory myopathies. Semin Arthritis Rheum. Published 2 February 2024. doi:10.
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