Sjögren's disease & overlap diseases
Oscillometric, greyscale- and novel color-Doppler-ultrasound indices of macrovascular damage in Sjögren’s: the SICARD cohort study
Authors' conclusion
In the largest cfPWV/US-cohort examined to date, pSS-patients had significantly higher aortic stiffness and atherosclerosis than controls. Aortic stiffness was predicted by systemic inflammation, alongside traditional CV risk factors.
Study context
- Population
- Patients with pSS and healthy controls (SICARD cohort)
- Participants
- 119 vs 97
- Exposure
- pSS vs healthy controls
- pSSn = 119
- Controlsn = 97reference
- Outcome
- Oscillometric (cfPWV), greyscale- and color-Doppler US indices of carotid and aortic damage
Methodological detailscase-control comparison with healthy controls
- Case-control comparison with healthy controls
Main finding
As reported in the abstract
- Significantly higher cfPWV in patients vs controls
- padj = 0.025
- Significantly higher cIMT in patients vs controls
- padj < 0.001
- Significantly higher calcification area in patients vs controls
- p = 0.013
Observational data: associations, not effects.
Further findings
Cardiovascular (CV) risk and subclinical damage in pSS
- High CV risk by mSCORE
- 5.7%
- Increased aortic stiffness by cfPWV
- 45.4%
- Carotid atherosclerosis by carotid ultrasound (US)
- 69.2%
Correlates of cfPWV in pSS
- Correlation with CRP, rho = 0.325
- P < 0.001
- Correlation with ESR, rho = 0.271
- P = 0.003
- Correlation with age, cholesterol, systolic blood pressure
- all; p < 0.01
ICA-RI and ICA-PI in pSS with further (non-rheumatological) autoimmune diseases
- ICA-RI and ICA-PI higher
- both; p < 0.05
Original publication
Oscillometric, greyscale- and novel color-Doppler-ultrasound indices of macrovascular damage in Sjögren’s: the SICARD cohort study. Arthritis Res Ther. Published 1 August 2025. doi:10.
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