Sjögren's disease & overlap diseases
Two-dimentional shear wave elastography as an alternative method of ultrasound for major salivary glands evaluation in Sjögren's disease
Authors' conclusion
Elastography seems to be a promising tool for providing additional diagnostic value in SjD.
Study context
- Population
- Patients with Sjögren's disease (SjD) and matched healthy controls; major salivary glands assessed by B-mode US and 2D-SWE (elasticity and shear wave velocity (SWV))
- Participants
- 52 vs 48
- Exposure
- SjD patients vs healthy controls; 2D-SWE vs B-mode US for major salivary glands (MSG) assessment
- SjDn = 52
- Healthy controlsn = 48reference
- Outcome
- Performance of 2D-SWE in assessing MSG involvement in SjD, compared with B-mode US, individually and combined
Methodological detailsage, sex and ethnicity-matched healthy controls
- Age, sex and ethnicity-matched healthy controls
Main finding
As reported in the abstract
Four MSG combined: elasticity, SWV and diagnostic performance
P < 0.001
- Elasticity AUC for SjD
- 0.982
- SWV AUC for SjD
- 0.983
- B-mode US AUC
- 0.852
- Combined 2D-SWE + B-mode US AUC (superior to B-mode US alone)
- 0.985
Observational data: associations, not effects.
Further findings
SWV, four MSG combined · higher in SjD
P < 0.001
Correlation of SWE parameters with ESSDAI glandular domain
- R (ESSDAI glandular domain), p=0.040
- 0.286
- No significant correlations with other clinical or laboratory features
Original publication
Two-dimentional shear wave elastography as an alternative method of ultrasound for major salivary glands evaluation in Sjögren's disease. Clin Exp Rheumatol. Published 28 July 2025. doi:10.
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