“Online survey of COVID-19 immunization and infection in patients with systemic juvenile idiopathic arthritis and adult-onset still’s disease.”
Authors' conclusion
The COVID-19 immunization was well tolerated by sJIA/AOSD patients even in this group of patients with severe disease.
Study context
- Population
- Patients and parents with self-reported systemic juvenile idiopathic arthritis (sJIA)/adult-onset Still’s disease (AOSD) on closed Facebook groups, June 27th–August 30th, 202217 excluded
- Participants
- 167 patients
- Exposure
- COVID-19 immunized vs unimmunized patients
- Immunizedn = 99
- Unimmunizedn = 51reference
- Outcome
- Safety and tolerability of COVID-19 immunization
Methodological detailsanonymous online survey, closed Facebook groups, self-reported sJIA/AOSD
- Anonymous online survey
- Closed Facebook groups
- Self-reported sJIA/AOSD
Main finding
As reported in the abstract
Immunization side effects (immunized patients)
- Patients reporting mostly mild immunization side effects
- 39
- Severe side effects: reports of disease flare
- 6
- Severe side effects: cardiac (pericarditis and atrial fibrillation)
- 2
- Patients with side effects lasting ≥ 8 days
- 7
- Patients developing AOSD following COVID-19 immunization
- 3
- Hospital admissions for immunization side effects (all among those developing AOSD)
- 2
Observational data: associations, not effects.
Further findings
Age
P < 0.001
History of disease flare or severe side effects with other immunizations
P < 0.001
History of disease complications: macrophage activation syndrome
History of disease complications: lung disease
History of disease complications: arthritis
History of disease complications: pericarditis/myocarditis
Disease flare after COVID-19 infection · trend
P > 0.05
COVID-19 infection
- Infected without full immunization
- 46
- Infected after 2 doses of immunization
- 33
Safety
| Outcome | Immunized | Unimmunized |
|---|---|---|
| Hospitalization/ICU admission and death from COVID-19 infection | ||
| Hospitalization | 1 | — not stated in the abstract |
| ICU admission leading to death | — not stated in the abstract | 1 |
— not stated in the abstract
Original publication
“Online survey of COVID-19 immunization and infection in patients with systemic juvenile idiopathic arthritis and adult-onset still’s disease.”. Pediatr Rheumatol Online J. Published 21 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →