Systemic sclerosis & Raynaud's
Occupational quantitative exposure to crystalline silica, solvents and pesticides and risk of clinical forms of systemic sclerosis
Authors' conclusion
This study emphasizes that many exposed SSc patients are unaware of their occupational exposure.
Study context
- Population
- SSc patients followed at Bordeaux University Hospital (France), VISS-EXPOSITION study
- Exposure
- Occupational exposure assessed by job-exposure matrices vs declaration, in relation to SSc clinical phenotypes
- Outcome
- Association between SSc clinical phenotypes and quantitative occupational exposure to crystalline silica, chlorinated solvents, trichloroethylene and pesticides
Methodological detailssingle-centre, job-exposure matrices
- Single-centre
- Job-exposure matrices
Main finding
As reported in the abstract
Proportion of patients exposed
| Outcome | Job-exposure matrices |
|---|---|
| Proportion of patients exposed | 10.1% |
| Pesticides | 25.9% |
| Chlorinated solvents | 7.9% |
| Trichlorethylene | 4.8% |
Observational data: associations, not effects.
Further findings
Crystalline silica exposure and pulmonary fibrotic SSc phenotype
| OR (95% CI) | ||
|---|---|---|
| Crystalline silica exposureNon-significant trend | 3.12 (0.80–12.15) | |
| 0.050.21520Odds ratio (log scale) |
Chlorinated solvent exposure and vascular SSc phenotype
| OR (95% CI) | ||
|---|---|---|
| Chlorinated solvent exposureNon-significant trend | 2.89 (0.93–8.95) | |
| 0.10.31310Odds ratio (log scale) |
Original publication
Occupational quantitative exposure to crystalline silica, solvents and pesticides and risk of clinical forms of systemic sclerosis. Rheumatology (Oxford). Published 14 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →