Spondyloarthritis & psoriatic arthritis
Neuropathic pain in spondyloarthritis: Decoding its prevalence, risk factors, and impact on disease activity
Authors' conclusion
Neuropathic pain is prevalent among patients with SpA and is significantly associated with disease activity assessments and management.
Study context
- Population
- Patients diagnosed with SpA (axial SpA (axSpA), psoriatic arthritis (PsA), undifferentiated peripheral SpA (p-SpA)), two tertiary rheumatology centres
- Participants
- 177 patients
- Outcome
- Prevalence of neuropathic pain (PD-Q, NPSI)
Methodological detailstwo tertiary rheumatology centres
- Two tertiary rheumatology centres
Main finding
As reported in the abstract
Neuropathic pain (PD-Q)
PainDETECT Questionnaire (PD-Q) score ≥19 (high likelihood of neuropathic pain)
22.2%
PD-Q score ≤12 (absence of significant neuropathic components)
64.9%
Mean PD-Q score (± SD)
11.5 ± 10.1
Observational data: associations, not effects.
Further findings
Neuropathic pain scores by sex and obesity (subgroups)
- Females had significantly higher scores for paroxysmal and evoked pain
- P < 0.05
- Obese patients had significantly higher scores across all Neuropathic Pain Symptom Inventory (NPSI) subscores
- P < 0.05
Correlation of neuropathic pain scores with disease activity indices
- DAPSA, moderate positive correlation (r)
- r = 0.46, p < 0.0001
- ASDAS-CRP, moderate positive correlation (r)
- r = 0.42, p < 0.01
Original publication
Neuropathic pain in spondyloarthritis: Decoding its prevalence, risk factors, and impact on disease activity. Semin Arthritis Rheum. Published 27 September 2024. doi:10.
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