Myocardial T1 mapping by cardiac magnetic resonance imaging shows early myocardial changes in treatment-naive patients with active rheumatoid arthritis and positive autoantibodies
Authors' conclusion
At the time of diagnosis, ERA patients with a higher disease activity (DAS28-CRP score ≥3.2) and both positive RF and ACPA showed prolonged T1 relaxation times in basal myocardial segments.
Study context
- Population
- Treatment-naive patients with early rheumatoid arthritis (RA) (symptom duration <1 year) without history of heart disease, and age- and sex-matched healthy volunteers; 1.5T cardiac magnetic resonance (CMR)39 early rheumatoid arthritis (ERA), 38 controls
- Exposure
- Treatment-naive early RA vs healthy controls
- Group An = 17
- Healthy controlsn = 38reference
- Outcome
- Myocardial global T1 relaxation time by CMR
- Follow-up
- At RA diagnosis
Methodological detailssingle-centre, age- and sex-matched healthy controls
- Single-centre
- Age- and sex-matched healthy controls
Main finding
As reported in the abstract
Myocardial global T1 relaxation time
P = 0.041
Observational data: associations, not effects.
Further findings
Segmental T1, group A vs controls
- Significant difference in T1 in the basal, mid inferior and mid anterolateral segments
Independent associations with prolonged global T1 (multivariate analysis)
- Female sex: 95% CI [5.62, 51.31] ms
- P = 0.016
- Group A status: 95% CI [4.65, 39.01] ms
- P = 0.014
Original publication
Myocardial T1 mapping by cardiac magnetic resonance imaging shows early myocardial changes in treatment-naive patients with active rheumatoid arthritis and positive autoantibodies. Clin Exp Rheumatol. Published 29 August 2023. doi:10.
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