Association of Interosseous Tendon Inflammation in the Hand With Different Early Arthritides in a 10‐Year Magnetic Resonance Imaging Study
Authors' conclusion
ITI occurs regularly in RA and other arthritides with preferential involvement of hand joints and increased acute-phase reactants. At the MCP joint level, ITI associates independently with joint tenderness and swelling.
Study context
- Population
- Patients presenting with various types of early arthritis, 2010–2020, Leiden Early Arthritis Cohort, with contrast-enhanced hand magnetic resonance imaging (MRI)
- Participants
- 1,205 patients
- Exposure
- Rheumatoid arthritis (RA) vs anti-citrullinated protein antibody (ACPA)-negative RA vs ACPA-positive RA vs Remitting seronegative symmetrical synovitis with pitting edema vs Connective tissue diseases vs Undifferentiated arthritis vs Psoriatic arthritis vs Inflammatory OA vs Reactive arthritis vs Crystal arthritis vs Peripheral spondylarthritis
- RAn = 532
- Outcome
- Prevalence of interosseous tendon inflammation (ITI) lateral of MCP joints 2-5 on MRI at diagnosis
- Follow-up
- Baseline
Methodological detailsMRI evaluated with blinding for clinical data, logistic regression and generalized estimating equations adjusted for age and synovitis/tenosynovitis/osteitis
- MRI evaluated with blinding for clinical data
- Logistic regression and generalized estimating equations adjusted for age and synovitis/tenosynovitis/osteitis
Main finding
As reported in the abstract
ITI prevalence at diagnosis
P = 0.53
- ITI more often in diagnoses with frequent arthritis of the hands
- P < 0.001
- ITI more often in diagnoses with increased acute-phase reactants
- P < 0.001
Observational data: associations, not effects.
Further findings
Within RA: association of ITI with local metacarpophalangeal (MCP) joint MRI inflammation
- Synovitis, OR
- 2.4 (1.7-3.4) (95% CI)
- Tenosynovitis, OR
- 2.4 (1.8-3.3) (95% CI)
- Osteitis, OR
- 2.2 (1.6-3.1) (95% CI)
Within RA: association of ITI with local MCP joint clinical signs
- Tenderness, OR
- 1.6 (1.2-2.1) (95% CI)
- Swelling, OR
- 1.8 (1.3-2.6) (95% CI)
- Independent of age and MRI-detected synovitis/tenosynovitis/osteitis
Original publication
Association of Interosseous Tendon Inflammation in the Hand With Different Early Arthritides in a 10‐Year Magnetic Resonance Imaging Study. Arthritis Rheumatol. Published 8 October 2023. doi:10.
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