Improving our understanding of the paradoxical protective effect of obesity on radiographic damage: a large magnetic resonance imaging-study in early arthritis
Main finding · MRI-detected osteitis per higher BMIResult — go to the resultβ 0.94 95% CI 0.93–0.96Authors' conclusion
High BMI relates to less osteitis at disease onset, which is not confined to RA. Within RA, high BMI and less osteitis associated with less MRI-detected erosive progression.
Study context
- Population
- Early arthritis patients consecutively included in Leiden Early Arthritis Clinic; baseline hand-and-foot MRI (RAMRIS-scored)149 RA with follow-up MRI
- Participants
- 1,029 participants
- Exposure
- Baseline BMI vs MRI-detected osteitis/synovitis and MRI-detected erosive progression
- RAn = 454
- Other arthritidesn = 575
- Outcome
- Association between baseline BMI and MRI-detected osteitis/synovitis
- Follow-up
- Disease onset
Methodological detailsLeiden Early Arthritis Clinic, consecutive inclusion, linear regression, Poisson mixed models
- Leiden Early Arthritis Clinic
- Consecutive inclusion
- Linear regression
- Poisson mixed models
Main finding
MRI-detected osteitis per higher BMI
β
0.94
95% CI 0.93–0.96
As reported in the abstract
Observational data: associations, not effects.
Further findings
MRI-detected osteitis per higher BMI, by subgroup · disease onset
| β (95% CI) | |
|---|---|
| ACPA-positive RA | 0.95 (0.93–0.97) |
| ACPA-negative RA | 0.97 (0.95–0.99) |
| Other arthritides | 0.98 (0.96–0.99) |
| Outcome | P value |
|---|---|
| MRI-detected erosive progression by overweight and obesity · 2 yearsOverweight · less erosive progression | P = 0.02 |
| MRI-detected erosive progression by overweight and obesity · 2 yearsObesity · less erosive progression | 0.03 |
| Osteitis and MRI-detected erosive progression · 2 yearsAssociated with erosive progression | P < 0.001 |
Original publication
Improving our understanding of the paradoxical protective effect of obesity on radiographic damage: a large magnetic resonance imaging-study in early arthritis. Rheumatology (Oxford). Published 30 June 2023. doi:10.
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