Spondyloarthritis & psoriatic arthritis
Multimorbidity phenotypes in ankylosing spondylitis and their association with disease activity and functional impairment: Data from the prospective study of outcomes in ankylosing spondylitis cohort
Authors' conclusion
Approximately 49 % of AS patients in the PSOAS cohort had multimorbidity and five distinct multimorbidity phenotypes were identified.
Study context
- Population
- Ankylosing spondylitis (AS) patients in the Prospective Study of Outcomes in Ankylosing Spondylitis (PSOAS) cohort; patient-reported morbidities (28 comorbidities, 3 EMMs) with prevalence ≥1 % within 3 years of enrollment
- Participants
- 1,270 patients9,885 visits
- Exposure
- Multimorbidity clusters vs no morbidities
- Depressionn = 321
- Hypertensionn = 284
- Uveitisn = 274
- No morbiditiesn = 238reference
- Miscellaneousn = 153
- Outcome
- Association of multimorbidity counts and clusters with disease activity (ASDAS-CRP) and functional status (BASFI) over time
Methodological detailsK-median clustering, generalized estimating equations, ASDAS-CRP and BASFI collected every 6 months
- K-median clustering
- Generalized estimating equations
- ASDAS-CRP and BASFI collected every 6 months
Main finding
As reported in the abstract
%
- Prevalence of MM2+ (≥2 morbidities)
- 49
- Prevalence of MM5+ (≥5 morbidities)
- 9
Observational data: associations, not effects.
Original publication
Multimorbidity phenotypes in ankylosing spondylitis and their association with disease activity and functional impairment: Data from the prospective study of outcomes in ankylosing spondylitis cohort. Semin Arthritis Rheum. Published 7 November 2023. doi:10.
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