Spondyloarthritis & psoriatic arthritis

The epidemiology of psoriatic arthritis in the UK: a health intelligence analysis of UK Primary Care Electronic Health Records 1991–2020

Rheumatology (Oxford)Published Retrospective cohort study

Authors' conclusion

The prevalence and incidence of PsA recorded in primary care has increased over the last three decades.

Study context

Population
UK primary care (Clinical Practice Research Datalink (CPRD)), 1 January 1991 to 31 December 2020
Participants
26,293 recorded psoriatic arthritis (PsA) cases
Exposure
Definite PsA vs Probable PsA
Outcome
Standardized annual prevalence and incidence of PsA
Follow-up
1991 to 2020
Methodological detailsBayesian multilevel regression with post-stratification, CPRD primary care electronic health records
  • Bayesian multilevel regression with post-stratification
  • CPRD primary care electronic health records

Main finding

As reported in the abstract

Standardized prevalence and incidence of PsA, 1991 to 2020

Standardized prevalence, 1991 to 2020 (twelve-fold increase)

0.03-0.37

Standardized incidence per 100 000 person years, 1991

8.97

Standardized incidence per 100 000 person years, 2020 (almost 2-fold increase)

15.08

Observational data: associations, not effects.

Further findings

Rates by sex, socioeconomic status, age and region

Rates similar between the sexes and across socioeconomic status over time
Rates strongly associated with age
Rates consistently highest in Northern Ireland

Original publication

The epidemiology of psoriatic arthritis in the UK: a health intelligence analysis of UK Primary Care Electronic Health Records 1991–2020. Rheumatology (Oxford). Published 2 November 2023. doi:10.1093/rheumatology/kead586

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