Spondyloarthritis & psoriatic arthritis
Molecular insights into the relationship between sustained C reactive protein (CRP) elevation and endothelial dysfunction in axial spondyloarthritis
Authors' conclusion
Sustained CRP elevation in axSpA is strongly linked to increased CV risk, endothelial dysfunction and atherosclerosis. IL-6, CDCP-1 and PON-3 emerge as key mediators connecting inflammation to CV risk.
Study context
- Population
- Patients with axial spondyloarthritis (axSpA)
- Participants
- 245 patients
- Comparison
- Sustained high CRP vs intermittent CRP elevation
- Outcome
- Sustained CRP elevation (>50% of readings elevated over past 5 years): prevalence and association with cardiovascular (CV) risk, atherosclerosis and endothelial dysfunction
Methodological detailsproteomic analysis (proximity extension assay), in vitro studies in human umbilical vein endothelial cells, retrospective CRP measurements from the past 5 years
- Proteomic analysis (proximity extension assay)
- In vitro studies in human umbilical vein endothelial cells
- Retrospective CRP measurements from the past 5 years
Main finding
As reported in the abstract
Sustained CRP elevation in axSpA patients
40%
Proteomic analysis: altered proteins identified
10
Further findings
Effects of anti-TNF-α therapy
- Reduced inflammatory markers, complement components and the atherogenic index; increased HDL, apolipoprotein A and PON-3; decreased IL-6 and CDCP-1
Original publication
Molecular insights into the relationship between sustained CRP elevation and endothelial dysfunction in axial spondyloarthritis. RMD Open. Published 5 July 2025. doi:10.
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