Lupus & antiphospholipid syndrome
Molecular endotypes of type 1 and type 2 SLE
Authors' conclusion
Gene co-expression analysis successfully identified unique transcriptional patterns that segregate type 1 SLE from type 2 SLE and further identified type 2 molecular features in patients with inactive SLE or FM and with active SLE with severe fatigue.
Study context
- Population
- Subjects with SLE selected by the presence of manifestations typical of type 1 and type 2 SLE
- Participants
- 18 subjects
- Comparison
- Type 1 SLE vs type 2 SLE
- Outcome
- Gene co-expression modules in peripheral blood
Methodological detailswhole-blood RNA sequencing, Multiscale Embedded Gene Co-expression Network Analysis
- Whole-blood RNA sequencing
- Multiscale Embedded Gene Co-expression Network Analysis
Main finding
As reported in the abstract
- Specific gene co-expression modules correlated with individual features of type 1 and type 2 SLE and effectively segregated type 1 from type 2 SLE samples
- Unique type 1 SLE enrichment: interferon, monocytes, T cells, cell cycle and neurotransmitter pathways
- Unique type 2 SLE enrichment: B cells and metabolic and neuromuscular pathways
Further findings
Type 2 SLE modules in other cohorts
- Type 2 SLE modules identified in subsets of previously reported patients with inactive SLE and idiopathic fibromyalgia (FM), and in subsets of patients with active SLE with a greater frequency of severe fatigue
Original publication
Molecular endotypes of type 1 and type 2 SLE. Lupus Sci Med. Published 30 January 2023. doi:10.
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